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Relative potentiation of WT CFTR currents by elexacaftor without or with GLPG1837 or I1421. Data represent means and SEs of 6-46 patches. Some data points are replotted from panel B. Statistical significance was tested by one-way ANOVA (*p =0.026;****p =6.3x10−6for elexacaftor + GLPG-1837 versus elexacaftor only,p =2.6x10−12for elexacaftor + GLPG-1837 versus GLPG-1837 only, andp= 9.3x10−5for elexacaftor + I1421 versus I1421 only). See alsoFigure S3.
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