Bar Plot from Scientific Research

Compound Z2075279358 (‘358) potentiates ΔF508 CFTR. CFBE41o−cells homozygous for ΔF508 CFTR were cultured with 1 μM lumacaftor to facilitate surface expression and pre-treated with 20 μM forskolin to activate ΔF508 CFTR by protein kinase A (PKA) phosphorylation. The relative potentiation was calculated as the ratio of flux rates with and without 1 μM potentiator. Data points represent the means and standard errors (SEs) of 6–8 measurements (each shown as a dot).

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