Left : the consensus motif for CTCF (MA1929.1 from the JASPAR database). Right : Enrichment and depletion in each indicated comparison of species-specific and shared oCGIs ( top: A-only, B-only, Shared) and species-specific and shared CTCF peaks ( left : A-only, B-only, Shared), compared to a null expectation of no association between oCGI turnover and peak turnover. Each 3 x 3 grid shows the results for a specific test examining oCGIs and their overlap with CTCF peaks. Each box in each grid is colored according to the level of enrichment over expectation (teal) or depletion (gray) of genome-wide sites that meet the criteria for that box. The color bar below each plot illustrates the level of enrichment or depletion over expectation. The filled upward-pointing triangles denote significant enrichment and open downward-pointing triangles denote significant depletion (q < 0.05, permutation test, BH-corrected; see Additional file 1 : Fig. S22 and Methods ).
