Illustration from Scientific Research

Schematic drawing of the generative model. The true methylation proportion for each CpG and cell type is drawn from one of two distributions: low (methylation probability Theta_low=0.1 ) and high (methylation probability Theta_high=0.9 ). Reads are generated from these proportions according to their cell type of origin. Read Length (RL) determines the number of CpGs on each read, and read depth (RD) was held constant at 30.

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