Relationships between species conservation and 5mC profiles. Balloon plots show standardized residuals from an association analysis (chi-square test of independence) between 5mC profiles and TF binding conservation categories for dog’s CEBPA and macaque’s CTCF TF binding events. Positive residuals indicate a positive association between the degree of species conservation and methylation profile, while negative residuals indicate negative associations. For example, dog’s CEBPA binding events with a flat profile are positively associated with higher levels of species conservation, while they are negatively associated with lineage-specific binding events. The size of the balloons is proportional to the percentage of contribution to the total Chi-square score, therefore highlighting the most influencing combination of species conservation and methylation profile to the overall statistics
