Scatter Plot from Scientific Research

Scope for the 1,3-difluorination of unactivated alkenes, 1(0.6 mmol, 130 mM), 0.5 : 1 [HF] : DCM, rt, 2 h. 5.5HF : amine=1 : 1 3HF . NEt3: 9HF.py. Isolated yields of product 2, containing <13 % 1,2-difluorinated product, which can be removed with additional HPLC purification. NMR yields are shown in parentheses, referenced to C6F6 internal standard. a) isolated with ca 10 % cyclization products (see Supporting Information for full details) b) 8HF : pyridine used instead of 5.5HF : amine.

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