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Heatmap representing the clinical scores at days 014 of HLA-DR1 mice infected with 200 PFUs of A/X31 (n= 6 mice), X31-HA-PKY (n= 6 mice), or mock infection (PBS) (n= 4 mice). Each cell represents the mean clinical score at each time point (scale on right-hand side). The clinical scoring point system was defined as follows: appearance, 03; reduced activity, 04; weight loss, 06 (full scoring system is shown inTable S3).pvalues are from two-way ANOVA, representing significant differences between the mean clinical scores of A/X31- and X31-HA-PKY-infected mice.
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