Referring to the positive association between HLA-A*02:06 and position 49 (associated amino acid: N) of HBV polymerase protein in the East Asian cohort. Each panel refers to the binding affinities of peptides to the associated HLA-A allele, with the frequency of the HLA allele within the cohort indicated in parentheses. Peptide amino-acid sequence is shown above each bar and the relative position of the HLA-associated HBV position is indicated in bold. x axis represents the binding affinity of each peptide, and y axis represents the fraction of carriers of the specified HLA-A allele for which the peptide is present in the viral sample. Shading represents whether the peptide is present as part of a mixture in the intra-host level (multiple peptides in the intra-host viral population) or not. The dotted lines indicate the threshold of a strong binder, defined as elution percentile rank less than 0.5%.
