Phylogenetic trees showing relationships between cancer cell populations in selected patients with known drivers of acquired resistance (JAK2andB2M) as well as a candidate driver of resistance (SEC24C/D) with corresponding graphs of the change in cancer cell fraction (CCF) of each cancer cell population including the given mutations. Each node indicates the subclone with specific mutations, and the CCF change of the same node is plotted for both pre- and post-treatment samples. See alsoFigures S2andS3andTable S3.
