Left: long-term potentiation (LTP) at 8 weeks after Mecp2 deletion. Inset graphs show representative electrophysiological traces at baseline and high-frequency stimulation. Right: pair-pulse ratio at 8 weeks after Mecp2 deletion (6–7 animals per condition per time point, with 12–30 slices per condition per time point). Data were analyzed with two-way ANOVA, and pvalue denotes genotype comparison****p< 0.0001; specific bins of paired pulse ratio were assessed after multiple comparisons correction;*p< 0.05,***p< 0.001,****p< 0.0001.
