The log2ratio of MeCP2 integrated signal was tabulated for individual genes; genes were then grouped as either persistently up- or downregulated or the background. Differences in the medians of each group was assessed by Kruskal-Wallis test followed by Dunn’s multiple comparisons correction;p< 0.001 andp< 0.0001. Dark gray displays a random sample of non-persistently regulated genes of nearly equal sample size as of the persistently dysregulated genes. Bottom row displays the distribution of padj values of Kruskal-Wallis tests followed by Dunn’s multiple comparisons comparing upregulated, downregulated, or non-persistently dysregulated genes to 1,000 bootstrapped simulated subsamples of non-persistently dysregulated genes. The percentage of simulations with padj< 0.05 are shown below the boxplots.
