Bacterial counts in the kidneys (A), bladder (B), and urine (C) of untreated (late control) vs. multiple cycles of ciprofloxacin-treated mice. 8-week-old female CBA/J mice were infected with 108CFU of the PAS133 strain. Treated mice were given ciprofloxacin 2.5 mg/kg subcutaneously twice daily for 48 h starting 48 h after the onset of infection. Treatment was repeated every 5 days such that mice received 1, 2, or 3 cycles of 48-h treatment with ciprofloxacin. Each dot represents a mouse. Lines and bars represent means ± SEM. Black dotted lines represent the limit of detection (1 colony for 100 L). Significance was determined using the Kruskal-Wallis test with adjustment for multiple comparisons. Allpvalues are shown; statistically significantpvalues (<0.05) are in red. Data are pooled from seven experiments,n= 3–8 mice per group per experiment.
