Bar Plot from Scientific Research

iRhom1/2 DKO HEK cells were transfected with different iRhom2 variants together with AP-tagged AREG or TNF as ADAM17 substrates. Medium was collected overnight and 2 M GW280264X (GW) or GI254023X (GI) were used when indicated. Error bars represent standard deviations (n= 3, three transfectants). A Dunnett’s test is performed by computing a Student’s t statistic for each transfection condition compared with the WT iRhom2 condition.*p< 0.0001.

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