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A diagram of the sheddase complex. ADAM17 is shown in yellow, with its prodomain in red. iRhom2 is colored blue. The first transmembrane domain of iRhom2 is labeled 1. The key D475 residue (discussed below) is shown as a turquoise circle. The furin cleavage site is indicated. See alsoFigures S1andS2.
#Illustration#Sheddase Complex#ADAM17#Prodomain#iRhom2#Transmembrane Domain#D475 Residue#Furin Cleavage Site
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