Workflow from Scientific Research
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Diabetic myopathy is characterized by impairments in both mature muscle fibers and myogenic precursor cells, which limits muscle regeneration when injured. These impairments include MuSC dysfunction, mitochondria-mediated apoptosis, and diminished cell growth and proliferation, which are regulated by multiple pathways such the PI3K-AKT-mTOR pathway, myostatin-SMAD2/SMAD3 signaling, NOTCH and WNT signaling, and the ENT-ADK-AMPK signaling axis.
#Workflow#Flowchart#Illustration#Diabetic Myopathy#Muscle Fibers#Myogenic Precursor Cells#Muscle Regeneration#MuSC Dysfunction#Mitochondria-Mediated Apoptosis#Cell Growth#Cell Proliferation#PI3K-AKT-mTOR Pathway#Myostatin-SMAD2/SMAD3 Signaling#NOTCH Signaling#WNT Signaling#ENT-ADK-AMPK Signaling Axis
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