Pathway from Scientific Research

Network view of pathway enrichment results corresponding to the analytes downregulated in both sexes after 8 weeks (the 8w_F-1_M-1 node in A). Nodes indicate enriched pathways (10% FDR), and an edge represents a pair of nodes with a similarity score of at least 0.3 between the gene sets driving each pathway enrichment. Node fill color indicates for which -omes a pathway is significant, whereas a black border color indicates if the pathway is significant in both the down- and upregulated nodes. Node size is proportional to the number of differential analyte sets for which the pathway is enriched. Clusters of enriched pathways were defined using Louvain community detection and are annotated with high-level biological themes.

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