Boxplot of PFS outcome score for each variant class, derived from CRC patients treated with BRAF, MEK and PD-1 inhibitor (PD-1i) combination therapy 28 . CBE and ABE perturb-seq scores are shown. *** P < 0.01, two-sided Wilcoxon rank-sum test compared with NT gRNAs. CBE; canonical drug resistance n = 7, driver n = 8, control n = 172, NT n = 39. ABE; drug addiction n = 11, canonical drug resistance n = 8, control n = 115, NT n = 39. Boxplots represent the median, IQR and whiskers are the lowest and highest values within 1.5x IQR. Control gRNAs are those that did not confer drug resistance in proliferation screens. See also Extended Data Figs. 7 – 9 .
