Bar Plot from Scientific Research

A reconstruction of the PER-POLE-P286R error signature by SBS mutational signatures of the COSMIC-V3 database, using non-negative least square regression ( Methods ). The linear coefficients for each of the four SBS signatures are shown in gray. The last graph in d shows the reconstructed vector (computed as a linear combination of the four SBS signatures) and the resulting cosine similarity to the original PER-POLE-P286R error signature.

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