Bar Plot from Scientific Research

FX12 and FC8 formulations show substantially improved efficiency for RNP delivery (with tdTom-g3(23ms) and EGFP-g6(23ms) as the sgRNAs) compared to the standard and cationic* formulations with different RNP dosages, even at subnanomolar RNP concentrations. Genome-editing efficiencies quantified on the basis of tdTom(+) or EGFP(-) signals using iGeoCas9 RNP–LNP complexes ( n = 4 for each group); data are presented as mean values with individual data points.

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