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BetR system-regulated genes shown in the context of their position on the SJC1043 chromosome and level of conservation acrossS. marcescens. Rings in the circular plot, from inside to out, show: (1) reverse-strand genes colored by conservation acrossS. marcescensusing Twilight,18according to the key; (2) black line representing the SJC1043 chromosome; (3) forward-strand genes colored by conservation (as ring 1); (4) log2fold change in transcript level for comparison between SJC1043 and SJC1043 BetR1051colored as a heatmap according to the key; (5) heatmap comparison of SJC1051 and SJC1051 BetR1043(as ring 4); (6) heatmap comparison of SJC1043 and SJC1043 Reg21070(as ring 4); and (7) location of genes significantly altered in any of the three comparisons, colored as part A except that those without specific categories are in black. The position of the T6SS_i3v1 gene cluster (not transcriptionally altered) is shown in gray and labeled. See alsoTable S2andData S2.

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