Density plot of mutations in thebetRlocus and 40 kb flanking regions, compared with SJC1043, across S. marcescens. Mutations are categorized by severity (defined using SnpEff): highframeshift, loss of start codon, loss or gain of stop codon (loss of function, red); moderatesingle amino acid change (non-synonymous, orange); modifierin intergenic region (yellow); lowno amino acid change (synonymous, green). Density plots are shown for the main lineages in S. marcescens, ordered from top to bottom as in the phylogenetic tree in (B). Above the plot is a to-scale representation of the genes in this region, with thebetRlocus highlighted by red labels and genes colored by level of conservation acrossmarcescensin a lineage-weighted manner (gene class, assigned using Twilight18).
