Left: schematic of the different experimental measurements, manifold and cell path inference approaches taken by VeloCycle, Dynamo (without metabolically labeled information) and Dynamo-Metabolic (with metabolically labeled information) models. Right: plot showing the estimated cell cycle period obtained by VeloCycle, Dynamo and Dynamo-Metabolic models. The violin plot displays the posterior distribution output by VeloCycle and the circles are individual evaluations of the LAP from different start/end cells; red stars indicate the means. The red dashed line indicates the median in d and j . The white dashed line indicates the mean of 500 posterior predictions and the black bar indicates the credibility interval (5th to 95th percentile) in a , b , f (right) and h . NS, not significant; ** P < 0.01.
