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Schematic of REEP1 domain organization and APH-C prediction. C-terminal REEP1 point mutations that cause relocalization to the bulk ER are circled in red. Amphipathic helices were predicted using heliquest ( https://heliquest.ipmc.cnrs.fr/ ) 70 . The arrows indicate the hydrophobic moments. Note that all mutations are either helix breakers or reside along the APH-C’s hydrophobic face.
#Workflow#Illustration#Chemical Structure#REEP1 Domain Organization#APH-C Prediction#C-terminal REEP1 Point Mutations#Amphipathic Helices
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