Manhattan plot from GWAS analysis of Hardy versus Ubiquitous strains from hspSiberia and hspIndigenousNAmerica (zoomed in between 1.50 and 1.55 megabase pairs; full plot shown in Extended Data Fig. 5). Genes are indicated by blue and red (differentiated genes) arrows. Green line indicates significance threshold (-log 10 (P) = 10, which is based on a Bayesian Wald test with a Bonferroni correction for multiple testing, using a significance threshold before correction of 3 x 10 –5, and 285,792 tested SNPs). Points are coloured based on FST (fixation index) values; half-points at the top of the plot indicate estimated P = 0 and FST = 1. HP1445 and so on are H. pylori genes based on the annotation of the 26695 strain.