Heterotypic fraction across models described in l . Assessment based on 22 coloured tumours for wild type + ENU, 249 for Apc het + ENU, 90 for Kras G12D/+ + ENU, 144 for Trp53 null + ENU and 185 for Kras G12D/+ ;Trp53 null + ENU. n = 20 biological replicates per group in a k .