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A revised model of BTSP induction. Synaptic inputs activate NMDAR-dependent signalling to prime the stimulated synapses. Combined synaptic inputs and postsynaptic activation of LTCCs lead to delayed plateau potentials. Intracellular Ca 2+ release is further facilitated by back-propagating action potentials (BpAPs) and activation of LTCCs. IP 3 -dependent calcium release from internal stores leads to delayed CaMKII activation (DDSC). DDSC acts as an instructive signal with an extended time window of 20–40 s. PLC, phospholipase C.

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