Side and top views of the superposition of the ATP-bound ABCD3 (gray) against the phytanoyl-CoA-bound ABCD3 (yellow). TMs are sequentially numbered, and phytanoyl-CoA molecules are shown as magenta sticks. Calpha atoms of Ile273 are displayed as spheres. The shifts of TM2, TM4, TM5 and TM6 are indicated by green, red, purple and blue arrows, respectively.