Table Image from Scientific Research

Sequence alignment of AetD with other enzymes in the HDO superfamily. The boxes show amino acid sequences that surround the conserved motifs within the alpha helices. The 3-His/3-carboxylate motifs (marked bold) are distributed into three core helices, a characteristic shared among HDO enzymes. One partially conserved residue in aux alpha2 is marked bold. This residue is a carboxylate ligand for non-substrate-triggered HDOs but a hydrophobic residue for substrate-triggered HDOs.

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