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Open access visualization of Heatmap, Line Plot, Single-Cell Calcium Response, Ratiometric Fura-2 Imaging, Vortioxetine Treatment
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Single-cell-resolved calcium response (Δ F / F 0 ) measured by ratiometric Fura-2 imaging over time at baseline (BASE) and after vortioxetine treatment (+VORT; 20 µM) across six cell lines ( n = 3,561 cells; see also Extended Data Fig. 7c–f ). Panels depict single-cell calcium responses (rows) over time (columns), stratified by the presence (Ψ) or absence (Ø) of calcium oscillations at baseline and VORT treatment. Representative single-cell traces ( n = 4 per heatmap) are depicted below.

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