Bar Plot from Scientific Research

Distribution of BM1 and BM2 subtypes across CMS subgroups. a The not detected group included patients with no ctDNA detected. b Patients with no ctDNA detected were excluded from the analysis. c The BM1 subtype is characterized by high KRAS/mTOR/AKT/4EBP1, epithelialmesenchymal transition (EMT) and immune infiltration, whereas the BM2 subtype is characterized by cell-cycle checkpoint dysregulation 5 . d CMS1 is characterized by MSI and immune patterns and enrichment for BRAF mutations; CMS2 by chromosomal instability and WNT activation; CMS3 by metabolic pattern and enrichment for KRAS mutations and CMS4 by EMT, angiogenesis and stromal infiltration 5 .

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