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To improve robustness to relatedness, population structure and imbalanced binary traits, we combined DeepRVAT with REGENIE (DeepRVAT + REGENIE), using DeepRVAT gene impairment scores as pseudodosages. Discoveries and replication across 34 quantitative traits, analogous to Fig. 2c,g , considering either the standard DeepRVAT or DeepRVAT + REGENIE. Shown are results obtained on different subcohorts of the UKBB 200k WES releaseunrelated individuals of European ancestry (European unrelated), all individuals of European ancestry (European incl. related) and all 200,583 individuals (all ancestries incl. related).

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