AUC differences when MILTON is trained on different feature set combinations for 1,299 ICD10 codes (time-agnostic model). Left, x axis represents median AUC 3k proteins+67 traits - median AUC 67 traits for matched ICD10 codes. Right, x axis represents median AUC 3k proteins+67 traits - median AUC 3k proteins for matched ICD10 codes. In b - f , each box plot shows median as center line, 25th percentile as lower box limit and 75th percentile as upper box limit; whiskers extend to 25th percentile - 1.5x interquartile range at the bottom and 75th percentile + 1.5x interquartile range at the top; points denote outliers. MWU, two-sided P values are shown in c - e .