Using data from GWASs for CRC, we identified 170 regions of interest. Data from MPRAs, epigenetic marks (ChIPseq), chromatin accessibility (ATACseq), gene expression (RNAseq) and longrange chromatin interactions (MicroC) were combined to derive an integrative score to prioritize the functional variants at each CRC risk locus. These variants were linked to target genes by analyzing colonspecific eQTLs and using SMR. In the GWAS plot, the coloured dots indicate the variants that are above the P value threshold. In the SMR plot, they represent the two different datasets (GWAS and eQTL). The coloured portions of DNA represent the genomic regions of interest that were studied.
