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Swirling EB differentiation protocol (screening protocol 2; Extended Data Fig. 1a ) showing the mesoderm induction and retinoid combinations used to differentiate RM TOM iPS cells for cohort 2 transplants. Cells were subjected to two mesoderm induction conditions and six retinoid exposure patterns before harvesting and cryopreservation on days 14–16. Partially created using BioRender.com .

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