Protein Structure from Scientific Research

Two different cryo-EM structures were obtained from a single sample of 1-EM with GABA and E2, viewed from the membrane plane. Presumed functional state (left, blue: desensitized; right, green: primed) and ensemble contribution as a percent of resolved particles are indicated above each structure. One subunit of each pentamer is colored darker for definition. E2 (yellow) and resolved lipids (gray) are shown as thick and thin sticks, respectively.

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