Mean number of NPCs per NE surface area (control: mean number per μm2= 13.7, 95% CI [10.1, 17.2],n= 8 grids, hyper-OS: mean number = 15.0 nm, 95% CI [12.8, 17.2],n= 4 grids and hypo-OS: mean number = 9.1 nm, 95% CI [7.8, 10.4],n= 4 grids). Statistical significance was tested using ordinary one-way ANOVA, significance level:*p< 0.05,**p< 0.01,***p< 0.001,pvalues are stated for non-significant results.