Protein Structure from Scientific Research

Top left: IR spoke with predicted AlphaFold models and only membrane-proximal Nups of IR (left). Top right: LR fitted with 8 copies of D. discoideum Nup210 homolog per asymmetric unit. Center row: CR contains one Y-complex (orange) per asymmetric unit. Highlighted are the Y-complex, Nup205-Nup93, and two copies of the Nup214 complex. Bottom row: three Y-complexes form the structural building block of the NR asymmetric unit. One copy is located close to the nuclear membrane (orange), one in the center (light orange), and a shorter outer Y-complex (yellow) with non-canonical conformation of Nup133 (arrowhead; see Figure S5). Each Y-complex and Nup205-Nup93 are highlighted.

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