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Schematic view of the dynamic energy landscape of the conformational space of the cytoplasmic shell (sum of both components), which explains the regulatory control of the cytoplasmic shell on the population distribution of RyR2 during systole. Figure 6a adapted from Marco C. Miotto et al., Structural analyzes of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment. Sci. Adv. 8,eabo1272(2022). https://doi.org/10.1126/sciadv.abo1272 under a CC BY license: https://creativecommons.org/licenses/by/4.0/ 10 .
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