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Table showing the correlation between the primed state conformation (RMSD), calstabin-2 k off , and onset age for the CPVT mutants tested (y.o.: years old) 53 . RMSD stands for the value of the normalized RMSD difference analysis of each structure. *The age of onset for WT RyR2 was considered as the average age when exercise-induced ventricular arrhythmias begin to be significant in the asymptomatic population 86 , 87 .
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