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RMSD normalized projection of WT RyR2 and RyR2-S2808D channels with different treatments. Values close to 0 or 1 indicate the conformation of the cytoplasmic shell is more similar to the closed WT RyR2 (PDB:7UA5), or the open WT RyR2 (PDB:7UA9), respectively. Negative values indicate the conformation of the cytoplasmic shell is more upward-inward than the closed state.
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