Scatter Plot from Scientific Research

DMS Pearson’s correlation (and corresponding P values) with measurements from previous studies 14 , 16 , 20 , 21 , 22 , 23 , 24 (Spearman’s correlation ( rho ) = 0.56, 0.93, 0.71, 0.59, 1, 0.94, from top-left to bottom-right plots). Titles indicate the gene for which nonsense variants were tested and the drug used to stimulate readthrough. The bottom-right plot does not show DMS estimates, but measurements of individual variants also tested in refs. 23 , 24 , which were used to validate the readthrough reporter. Note that the readthrough scales differ across some of the studies, illustrating how differences in the assay, conditions and reporter influence the absolute readthrough.

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