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Schematic illustration of WT and Pik3ca H1047R/wt cell behavior in esophageal epithelium. Model predictions for the proportions of cell division outcomes for each genotype. Pik3ca H1047R/wt cells produce an excess of progenitor over differentiating cells per average cell division, driving clonal expansion even with the rate of mutant cell division being the same as WT cells.

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