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Protocol 2. Cre-Pik3ca H1047R-YFP/wt mice were treated with DEN for 8 weeks followed by Cre induction. A subgroup of animals was then treated with the tumor promoter sorafenib (SOR) for 6 weeks. Tissues were collected before exceeding the permitted humane endpoint ( Methods ) or 1 year post-DEN treatment. Control groups received all treatments but were uninduced.

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