Bar Plot from Scientific Research

CRISPRi suppression or pooled CRISPR knockout increases HDR efficiency from linear dsDNA templates in multiple cell backgrounds. GFP was introduced into RAB11A and FBL loci in HeLa cells ( n = 8, P = 1.1 x 10 -6 for RAB11A and n = 4, P = 2.4 x 10 -7 for FBL , respectively), activated T cells (from Fig. 4e , with RAB11A only) and Jurkat cells ( FBL only) ( n = 2). Each dot represents an individual biological replicate measurement.

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