RPE-1 hTERT TREX1 –/– cells perform high levels of HDR, and TREX1 cDNA complementation abrogates HDR as measured by the BFP-to-GFP assay. Dots ( n = 8 for RPE1 wild-type and RPE-1 TREX1 –/– , n = 5 for RPE-1 hTERT TREX1 –/– + wild-type TREX1 cDNA) represent individual biological replicate measurements; bars represent the mean values; and error bars represent the standard deviation.
