Performance (Pearson correlation; x axis) of methods (y axis) for each cell type (facet label). Methods include comparator baseline methods, participant methods ranking within the top three in either or both sub-Challenges, or methods having the best mean performance across datasets for any cell type. Performance indicated separately (by color) for Challenge validation (Healthy), in silico scRNA-seq-derived CRC [Pelka (CRC)], and in silico scRNA-seq-derived BRCA [Wu (BRCA)] datasets. Mean performance is calculated across these three datasets. Challenge validation performance is itself the mean performance across the eight healthy Challenge validation datasets (e.g., distinguished by in silico versus in vitro, as in Fig. S20 ). Methods ordered according to their mean performance across the three datasets and the cell types, and cell types ordered according to the max over methods of their mean performance across the three datasets. Source data are provided as a Source Data file.
