Method performance was also quantified according to cross-cell type, within-sample correlation (Fig. 4 ), specificity (i.e., the spillover prediction from a purified cell type into a different cell type; Fig. 5 ), and sensitivity (i.e., the limit of detection for a particular cell type; Fig. 6 ). A D Created with BioRender.com, released under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International license.