Illustration from Scientific Research

Schematic of PglX domain organisation with predicted MmeI-like DNA methyltransferase and adenine-specific DNA methylase regions denoted by square brackets. The methyltransferase domain (yellow) contains GxG (bright green) and NPPY (cyan) amino acid motifs responsible for S-adenosyl-L-methionine (SAM) binding and transfer of methyl group to an adenine residue, respectively, indicative of a -class amino-methyltransferase. The C-terminal region (light orange) is separated from the target recognition domain (TRD, red), by a long double helical spacer (light blue). The N-terminal domain contains an additional helical bundle (light purple) upstream of the methyltransferase domain.

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