Illustration from Scientific Research

Schematic representation of the features of the four clusters of senescent cells identified using overrepresentation analysis, highlighting the clusters over-represented in OIS (2 and 4) and in OIS-shA1 (1 and 3), respectively. Although inflammatory SASP (iSASP) and p16 have been collectively considered senescence hallmarks, they represent distinct types of senescence at the single-cell level. Clusters 3 and 4 express cell-cycle genes and Cluster 4 resembles the previously described NOTCH-related ‘early phase senescence’ with augmented fibroblastic features 33 , 34 .

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