Body weight and SMG weight of adult male and female mice normalized to body weight and WT. Error bars are SM. Body weight: n = 65 (WT-male), 51 (DKO-male), 49 (WT-female) and 35 (DKO-female) mice. SMG weight: n = 63 (WT-male), 46 (DKO-male), 47 (WT-female) and 42 (DKO-female). Unpaired two-tailed t -test. *** p < 0.0001, compared to WT.